There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
نویسندگان
چکیده
منابع مشابه
Presumed pseudokinase VRK3 functions as a BAF kinase.
Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity. Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports suggest that VRK3 acts as an active kinase as well as a signaling scaffold in cells. Here, we demonstrate that VRK3 phosphoryla...
متن کاملp63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...
متن کاملThere is more to life stories than memories.
Current theories focus on the role of specific memories in organising the life story. However, temporally extended structures of autobiographical memory, like lifetime periods and mini-narratives (here termed chapters), may also play a central role in the organisation of the life story. Here, 30 elderly participants were asked to tell their life story in a free format. The life stories were div...
متن کاملMethylation and mRNA expression levels of P15, death-associated protein kinase, and suppressor of cytokine signaling-1 genes in multiple myeloma
Objective(s): The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). Materials and Methods: The bone marrow samples of 54 MM patients were collected and the methylation status of the P15, DAPK, and SOCS1 gene promoter regions was dete...
متن کاملCell death machinery makes life more robust
CED-3, a protein that is essential for programmed cell death, also has an unexpected role in the regulation of non-apoptotic genes during normal development.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2021
ISSN: 0021-9258
DOI: 10.1016/j.jbc.2021.100705